Abstract: The remarkable progress of veterinary antimicrobial drugs （AMDs） pharmacokinetics/ pharmacodynamics（PK/PD）models has been made in recent years. Understanding the basic concept of PK/PD model and optimizing the dosage regimen can improve the antibacterial effect of AMDs and reduce the occurrence of drug resistance. This paper introduces the research methods and progress of PK/PD model，as well as the challenges and application prospects of PK/PD model in veterinary AMDs and its future development trend，and provide a theoretical basis for the research of PK/PD model for veterinary AMDs.

Key words: Pharmacokinetics/Pharmacodynamics Models, Veterinary Antimicrobial Drugs, Dosage Regimen, Bacterial Resistance

摘要： 近年来关于兽用抗菌药物的药代动力学/药效学（Pharmacokinetics/Pharmacodynam? ics，PK/PD）同步模型的研究取得较大进展。了解PK/PD同步模型的基本概念，利用PK/PD同 步模型优化给药方案，可以增强药物的抗菌效果，减少耐药性的发生。该文介绍了PK/PD同步 模型的研究方法和应用进展，以及PK/PD同步模型在兽药领域面临的挑战和应用前景，以期提 高对兽药PK/PD同步模型及其未来发展趋势的认识，为兽用抗菌药物PK/PD同步模型研究开 展提供一定理论基础。

关键词: PK/PD同步模型, 抗菌药物, 给药方案, 细菌耐药性