Abstract: Goose astrovirus（GAstV）is a newly member of the astrovirus genus discovered recently in China，which mainly affects goslings under 3 weeks of age. The infection rate is as high as 80%，and the mortality rate can beas high as 50%. The goslings infected with GAstV but survived showed growth inhibition and decreased immune level，and were more susceptible to other pathogens. GAstV could be transmitted vertically as well as horizontally by fecal?oral route，and also showed the characteristics of cross ? host transmission. Up to now，due to the lack of commercialized vaccine and other biological products for this virus and the slow progress of the research on its pathogenic mechanism，the scientific formulation and effective implementation of prevention and control measures for this disease still lacks a sufficient theoretical basis and a sound veterinary system，resulting in the grim situation of this disease prevention and control，which has caused great economic losses to the goose industry in China. In this paper，abrief review of the etiology，epidemiology，pathogenicity，immune response and its pathogenic mechanism of GAstV was carried out，with a view to providing a reference for the in ? depth study of GAstV and the preliminary development of preventive and control measures.

Key words: Goose astrovirus, Etiology, Epidemiology, Pathogenicity, Immune response, Pathogenic mechanism

摘要： 鹅星状病毒（Goose astrovirus，GAstV）是我国近年来新发现的一种星状病毒属成员，主要危害 3 周龄以下雏鹅。雏鹅感染后以内脏器官表面和关节腔中显著的尿酸盐沉积为特征；其感染率高达 80%，死亡率可达 50%；未死亡雏鹅则出现生长抑制和免疫水平降低等现象，更易受到其他病原的侵害。GAstV 既够能通过粪口途径水平传播，也可垂直传播，同时还具备跨宿主传播的能力。目前该病毒致病机制的研究进展较为缓慢且尚无针对该病的商品化生物制品，使得在制定该病的科学防控措施时仍缺乏充分的理论依据和健全的药物配套，导致该疾病的防控形势依然严峻，给我国养鹅业造成了巨大的经济损失。该文围绕 GAstV 的病原学、流行情况、致病性、免疫应答及其致病机制等方面进行了简要综述，以期为 GAstV 的深入研究和防控措施的初步制定提供参考。

关键词: 鹅星状病毒, 病原学, 流行病学, 致病性, 免疫应答, 致病机制