Abstract: Porcine epidemic diarrhea virus（PEDV）is one of the main pathogens causing viral diarrhea in pigs， causing huge economic losses to the pig industry in my country and even the world. Clinically，piglets within 7 days of age have the highest morbidity rate，and the case fatality rate can reach 100% . At present，vaccines are still an important means of preventing PEDV. This paper analyzes the reasons for the poor immune effect of traditional vaccines from the aspects of epidemiology，clinical symptoms and vaccine research status，and expounds the basic situation of PEDV and its immune prevention and control，so as to provide theoretical reference for the development of new vaccines.

Key words: Porcine epidemic diarrhea； Vaccine； Variation； Spike protein

摘要： 猪流行性腹泻病毒（Porcine epidemic diarrhea virus，PEDV）是目前引起猪群病毒性 腹泻的主要病原之一，给我国乃至世界养猪业造成巨大经济损失。临床上7日龄以内的仔猪 发病率最高，病死率可达100%，目前，疫苗仍是预防PEDV的重要手段。本文从流行病学、临 床症状与疫苗研究现状等方面分析传统疫苗免疫效果差的原因，阐述PEDV的基本情况及其 免疫防控，为新型疫苗研制提供理论参考。

关键词: 猪流行性腹泻； 疫苗； 变异； S蛋白