Abstract: Intestinal barrier is an important basis for animals to maintain homeostasis. Many factors can destroy the integrity of intestinal barrier，leading to bacterial and viral invasion and systemic diseases. Bile acid，as an important component of bile，is synthesized from the liver with cholesterol as raw material and can be discharged into the digestive tract together with bile under the stimulation of exogenous food and related hormones. Bile acids not only emulsify fat，promote intestinal absorption of lipid，regulate liver function，increase energy consumption and other functions，but also play an important role in maintaining intestinal homeostasis. Bile acid receptor are distribution inthe animal internal organs in the body，after bile acid or bile acid analogues activation play a physiological role， and play a role in different organs of mechanism is different，in the intestinal tract，mainly through the bile acid and bile acid receptor and intestinal flora in regulating intestinal steady state，the three interactions，and checks and balances. This review focuses on the roles and mechanisms of bile acids and their receptors in intestinal barrier homeostasis.

Key words: Bile acid； Bile acid receptor； The intestinal steady?state

摘要： 肠道屏障是动物维持机体稳态的重要基础，许多因素均可破坏其完整性，进而导致 细菌、病毒侵袭，引发全身性疾病。胆汁酸作为胆汁的重要成分，由肝以胆固醇为原料进行合 成，能在外源食物及相关激素的刺激下与胆汁一同被排入消化道内。胆汁酸不仅具有脂肪乳 化、促进肠道吸收脂质、调节肝脏功能、增加能量消耗等功能，还对维持肠道稳态具有重要作 用。胆汁酸受体在动物体内各个脏器均有分布，经胆汁酸或胆汁酸类似物激活后发挥其生理 作用，而且在不同的脏器中发挥作用的机制有所不同，在肠道内，主要是通过胆汁酸与胆汁酸 受体以及肠道菌群来共同调节肠道稳态，三者相互作用，又相互制衡。本文主要综述了胆汁 酸及其受体在动物肠道屏障功能稳态中的作用及其内在机制。

关键词: 胆汁酸； 胆汁酸受体； 肠道稳态