关键词: 鹅星状病毒, 病原学, 流行病学, 致病性, 免疫应答, 致病机制

Abstract: Goose astrovirus（GAstV）is a newly member of the astrovirus genus discovered recently in China，which mainly affects goslings under 3 weeks of age. The infection rate is as high as 80%，and the mortality rate can beas high as 50%. The goslings infected with GAstV but survived showed growth inhibition and decreased immune level，and were more susceptible to other pathogens. GAstV could be transmitted vertically as well as horizontally by fecal?oral route，and also showed the characteristics of cross ? host transmission. Up to now，due to the lack of commercialized vaccine and other biological products for this virus and the slow progress of the research on its pathogenic mechanism，the scientific formulation and effective implementation of prevention and control measures for this disease still lacks a sufficient theoretical basis and a sound veterinary system，resulting in the grim situation of this disease prevention and control，which has caused great economic losses to the goose industry in China. In this paper，abrief review of the etiology，epidemiology，pathogenicity，immune response and its pathogenic mechanism of GAstV was carried out，with a view to providing a reference for the in ? depth study of GAstV and the preliminary development of preventive and control measures.

Key words: Goose astrovirus, Etiology, Epidemiology, Pathogenicity, Immune response, Pathogenic mechanism