The domestic outbreak of the African Swine Fever in 2018 has had a profound impact on the pig industry. To optimize the layout of the pig industry and improve the level of animal epidemic prevention and control, the State Council has put forward suggestions for changing the pork supply mode. This paper initially envisaged the possible problems of animal epidemic risk management and control in Shenzhen under the new model of pork supply, explored the introduction of a theoretical model of risk analysis, straighten out the process of animal epidemic risk analysis, and built a trans??regional animal health risk prevention and control system. In the future, the system will play the role of locking core risk control points, issuing animal epidemic risk early warnings, and eliminating specific animal epidemic risks, so as to ensure the quality and safety of deep pork from the source.