Abstract: This study aimed to evaluate the effect of Callicarpa Nudiflora Hook. et Am. granules on the blood physiological and biochemical indexes of target animal dogs. A total of 20 Chinese pastoral dogs were divided into 4 groups，with 5 dogs in each group. Dogs in the control group were fed a basal diet，and others in experiment groups were fed basal diet supplemented 0.1 g/kg BW and 0.3 g/kg BW Callicarpa Nudiflora Hook. et Am. Granules， respectively. The experiment lasted for 10 days. The clinical signs，body weight，and blood physiology and biochemistry of dogs were evaluated. The results showed that the clinical signs of the experimental dogs were normal after oral administration of different doses of Callicarpa Nudiflora Hook. et Am. Granules，and there was no obvious effect. There was no significant difference in the main blood physiological and biochemical indexes between the test group and the blank control group（P>0.05）. The results showed that Callicarpa Nudiflora Hook. granules had no significant effect on the clinical signs，body weight，and blood physiological and biochemical indexes of the experimental dogs.

Key words: Callicarpa Nudiflora Hook. Granule, Dog, Blood physiological and biochemical indicators

摘要： 为研究裸花紫珠颗粒对靶动物犬血液生理生化指标的影响，该文将20只犬（中华田 园犬）按完全随机方法分成4个组，每组5只，分别为第1组（空白对照组）、第2组（裸花紫珠颗 粒0.1 g/kg·bw）、第3组（裸花紫珠颗粒0.3 g/kg·bw）、第4组（裸花紫珠颗粒0.5 g/kg·bw），采用口 服给药的方法，每天给药1次，连续给药10 d，在试验期间观察试验犬临床体征表现，并评价 不同剂量裸花紫珠颗粒对试验犬的体重和血液生理生化指标的影响。结果显示，试验犬口服 不同剂量裸花紫珠颗粒连续10 d，临床体征表现正常，未见明显的影响，犬只血液生理生化指 标与空白对照组相比无显著差异（P>0.05）。结果表明，裸花紫珠颗粒对试验犬只的临床体征、 体重和血液生理生化指标无明显影响，安全性较好。

关键词: 裸花紫珠颗粒, 犬, 血液生理生化指标