关键词: 猪肺炎支原体；流行情况；发病机制；疫苗免疫；净化

Abstract: Mycoplasmal pneumonia of swine （MPS） is a chronic，wasting infectious disease caused by Mycoplasma hyopneumoniae（Mhp），characterized mainly by coughing and dyspnea. It is also known as swine enzootic pneumonia（EP）or swine chronic respiratory disease. With the intensification of large?scale farming，the infection rate of this disease in domestic pig farms remains high. Although Mhp infection has a low mortality rate，it can increase the culling rate of infected pigs，raise the feed?to?meat ratio，reduce daily weight gain，slow growth，and extend the time to market for finishing pigs，severely undermining the economic efficiency of swine herds. Conventional preventive and control measures for Mhp include vaccination and antibiotic treatment. However，the immune evasion mechanisms formed by Mhp after invading the host，secondary infections，and antibiotic resistance significantly diminish the effectiveness of both Vaccination and antibiotic therapy，making it difficult to eradicate Mhp once it enters a pig herd.To address this challenge，this paper discusses the current status of Mhp infection and control from four aspects：the harmful effects of Mhp，its pathogenic mechanisms，epidemiology，and preventive measures，with the aim of providing a reference for the control of this disease.

Key words: Mycoplasma hyopneumoniae；Epidemiology；Pathogenesis；Vaccine immunization；Eradication