关键词: 白油佐剂； 完全弗氏佐剂； 不完全弗氏佐剂； MF59?； AS 佐剂； Mon? tanides佐剂

Abstract: Emulsion immune adjuvant，also known as oil adjuvant，is a kind of immune adjuvant that encapsulates antigens in various oil phases to provide a reservoir for immunogens and enhances the body 's specific immune response to antigens by presenting antigens to immune cells. Since the application of emulsion adjuvants was first reported in 1916，emulsion adjuvants have become an indispensable factor in vaccines research and development for more than 100 years，providing a material guarantee for safer and more efficacy vaccines against various infectious diseases in humans and animals. With the continuous development of modern vaccinology，the research and development of new vaccines have put forward higher requirements for adjuvants. Knowing the composition and understanding the immune mechanism of adjuvants are the premise for the application of adjuvants in vaccine research and development. In order to provide a theoretical reference for emulsion adjuvants in clinical use，in this paper， commonly used and commercialized emulsion adjuvants，such as white oil adjuvants，complete Freund 's adjuvant （CFA），incomplete Freund 's adjuvant（IFA），MF59?，AS adjuvants and Montanides adjuvants were chosen，and their components，immune mechanism and clinical application were reviewed.

Key words: Mineral oil adjuvants； Complete Freund’s Adjuvant； Incomplete Freund’s adjuvant； MF59?； Adjuvant systems； Montanides adjuvant