广东畜牧兽医科技 ›› 2023, Vol. 48 ›› Issue (5): 27-32.DOI: 10.19978/j.cnki.xmsy.2023.05.05

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鸡传染性法氏囊病疫苗的研究进展

张旭知,孙彩宜,徐少珠,张国丽,齐冬梅*   

  1. (广东永顺生物制药股份有限公司,广东 广州 511356)
  • 出版日期:2023-10-18 发布日期:2023-10-18
  • 通讯作者: 齐冬梅

Research Progress of Infectious Bursal Disease Vaccines

ZHANG Xuzhi,SUN Caiyi,XU Shaozhu,ZHANG Guoli,QI Dongmei**   

  1. (Guangdong Winsun Bio?Phamaceutical Co.,Ltd,Guangzhou Guangdong 511356)
  • Online:2023-10-18 Published:2023-10-18

摘要: 鸡传染性法氏囊病(Infectious Bursal Disease,IBD)是由鸡传染性法氏囊病病毒(In? fectious Bursal Disease Virus,IBDV)引起的、主要侵害幼龄鸡的一种急性、高度接触性传染病, 其主要特征是导致法氏囊的严重损伤和免疫抑制。自20世纪80年代以来,IBDV在很多国家 和地区均发现以毒力增强为主要特征的抗原变异,出现了变异毒株(vIBDV)和超强毒株(vvIB? DV)。IBD在全球范围内给养禽业造成了重大的经济损失。目前主要采取疫苗接种和生物安 全相结合的综合防控措施,该文对已商品化的和正在研发中的IBD减毒活疫苗、全病毒灭活疫 苗、免疫复合物疫苗、重组载体活疫苗、亚单位疫苗、DNA疫苗等进行综述,以期为更好的防控 IBD提供理论参考。

关键词: 鸡传染性法氏囊病; 减毒活疫苗; 灭活疫苗; 免疫复合物疫苗; 重组载体 活疫苗; 亚单位疫苗

Abstract: Infectious Bursal Disease(IBD)is an acute,highly contagious infectious disease caused by infectious bursal disease virus(IBDV)mainly affecting young chickens. It is characterized by severe injury of bursa of Fabricius and immunosuppression. Since 1980s,IBDV has been found in many countries and regions. In addition,IBDV variants with increased virulence,namely variant IBDV(vIBDV)and variant/very virulent IBDV(vvIBDV)had emerged. IBD cause significant economic losses to the poultry industry worldwide. At present,comprehensive prevention and control measures combining vaccination and biosafety are mainly adopted. In this paper,IBD attenuated live vaccines,inactivated vaccines,immune complex vaccines,recombinant vector live vaccines,subunit vaccines and DNA vaccines that have been commercialized or are under development are reviewed,in order to provide theoretical reference for better prevention and control of IBD.

Key words: Infectious Bursal Disease; Attenuated live vaccine; Inactivated vaccine; Immune complex vaccine; Recombinant vector live vaccine; Subunit vaccine

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