超声造影在犬肝脏肿瘤诊断中的应用与研究进展

doi:10.19978/j.cnki.xmsy.2022.03.20

摘要/Abstract

摘要： 在宠物临床诊疗中，超声检查已经成为常规检查手段，特别是在肝脏、脾脏、心脏与肾脏等软组织器官中的应用更有优势；但由于肝脏结构复杂且位置特殊，肝脏常规超声检查对诊断肝脏疾病有一定难度。超声造影有着独特的优势，尤其是鉴别肝脏良恶性病变和恶性病变诊断，该技术已成为人类医学肝脏疾病诊断的重要手段，但在兽医临床诊断中的应用较少。本文介绍超声造影技术的原理、理论基础及其在犬肝脏肿瘤诊断中的临床应用与研究进展。

关键词: 超声造影；对比增强；犬；肝肿瘤

Abstract: Ultrasound examination has become a routine examination method in clinical diagnosis and treatment of pets，especially in soft tissues such as liver，spleen，heart and kidney. However，due to the complex structure and special location of the liver，it is difficult to diagnose liver diseases by routine ultrasound examination. The contrast? enhanced ultrasound technology has become an important means for the diagnosis of liver diseases in human medicine， but it is rarely used in veterinary clinics. The contrast?enhanced ultrasound has unique advantages，especially in the diagnosis of liver benign and malignant lesions. In this review，we summarized the principle，theoretical basis， clinical application，and research progress of contrast?enhanced ultrasound in the diagnosis of canine liver tumors ．

Key words: Contrast?enhanced Ultrasound； Contrast Enhancement； Canine； Liver Tumor

中图分类号:

S858.292

蔡洁璇，张旭銮，谢浩铭，陈义洲*. 超声造影在犬肝脏肿瘤诊断中的应用与研究进展[J]. 广东畜牧兽医科技, 2022, 47(3): 102-105.

CAI Jiexuan，ZHANG Xuluan，XIE Haoming，CHEN Yizhou*. The application and research progress in contrast⁃enhanced ultrasound in diagnosis of canine liver tumors[J]. Guangdong Journal of Animal and Veterinary Science, 2022, 47(3): 102-105.

参考文献

［1］王振铎，边倩. 超声造影技术在肝肿瘤诊察中的应用分析［J］. 电脑知识与技术，2020，16（1）：263. ［2］ HAERS H，SAUNDERS J H. Review of Clinical Characteristics and Applications of Contrast?Enhanced Ultrasonography in Dogs ［J］. Journal of the American Veterinary Medical Association， 2009，234（4）：460?470. ［3］ BLOMLEY M J K. Science， medicine， and the future： Microbubble contrast agents：a new era in ultrasound［J］. British Medical Journal，2001，322（7296）：1222?1225. ［4］ JONG N DE，FRINKING P J ，BOUAKAZ A，et al. Detection Procedures of Ultrasound Contrast Agents［J］. Ultrasonics， 2000，38（1?8）：87?92. ［5］ CORREAS J ? M，BRIDAL L，LESAVRE A，et al. Ultrasound Contrast Agents：Properties，Principles of Action，Tolerance， and Artifacts［J］. European Radiology，2001，11（8）：1316– 1328. ［6］ WDOWIAK M，RYCHLIK A，NIERADKA R，et al. Contrast ? enhanced ultrasonography（CEUS）in canine liver examination ［J］. Polish Journal of Veterinary Sciences，2010，13（4）：767? 773. ［7］ NYMAN H T，KRISTENSEN A T，Kjelgaard?Hansen M，et al. Contrast ? enhanced ultrasonography in normal canine liver. Evaluation of imaging and safety parameters［J］. Veterinary Radiology & Ultrasound，2005，46（3）：243?250. ［8］李前勇，张德志，张见华，等. 犬肝、胆超声造影技术初探［C］. 中国畜牧兽医学会兽医影像技术学分会第十五次学术研讨会. 2016：30?35. ［9］ MAROLF A J. Diagnostic Imaging of the Hepatobiliary System ［J］. Veterinary Clinics of North America： Small Animal Practice，2017，47（3）：555?568. ［10］KANEMOTO H， OHNO K， NAKASHIMA K， et al. Characterization of canine focal liver lesions with contrast ? enhanced ultrasound using a novel contrast agent ? sonazoid［J］. Veterinary Radiology & Ultrasound，2009，50（2）：188?194. ［11］OBRADOVICH D. Small Animal Clinical Oncology［M］. CRC Press. 2016：54?60. ［12］NAKAMURA K，TAKAGI S，SASAKI N，et al. Contrast ? enhanced ultrasonography for characterization of canine focal liver lesions［J］. Veterinary Radiology & Ultrasound，2010，51 （1）：79?85. ［13］O’BRIEN R T. Improved detection of metastatic hepatic hemangiosarcoma nodules with contrast ultrasound in three dogs ［J］. Veterinary Radiology & Ultrasound，2007，48（2）：146 ? 148. ［14］KUTARA K，ASANO K，KITO A，et al. Contrast Harmonic Imaging of Canine Hepatic Tumors［J］. Journal of Veterinary Medical Science，2006，68（5）：433?438. ［15］GNUDI G，VOLTA A，MANFREDI S，et al. Contrast?Enhanced Ultrasonography for Characterization of Liver Lesions in Dogs and Cats［M］. Springer Berlin Heidelberg. 2011：109?114. ［16］O’BRIEN R T，IANI M，MATHESON J，et al. Contrast harmonic ultrasound of spontaneous liver nodules in 32 dogs［J］. Veterinary Radiology & Ultrasound，2004，45（6）：547?553. ［17］BRANNIGAN M，BURNS P N，WILSON S R. Blood Flow Patterns in Focal Liver Lesions at Microbubble ? Enhanced US ［J］. RadioGraphics，2004，24（4）：921?935. ［18］PATNAIK A K，HURVITZ A I，LIEBERMAN P H. Canine Hepatic Neoplasms：A Clinicopathologic Study［J］. Veterinary Pathology，1980，17（5）：553?564. ［19］BANZATO T，RUBINI G，ORLANDI R，et al. Contrast ? Enhanced Ultrasound Features of Hepatocellular Carcinoma in Dogs［J］. Veterinary Record，2020，186（6）：187?187. ［20］SMITH A N. Hemangiosarcoma in Dogs and Cats［J］. Veterinary Clinics of North America：Small Animal Practice，2003，33 （3）：533?552. ［21］MARTíNEZ ? SOGUES L， VILA A， ROURA X， et al. Hypercalcemia of Malignancy in a Dog Diagnosed With Cholangiocellular Carcinoma［J］. Topics in Companion Animal Medicine，2019，35：1?5. ［22］BURTI S，ZOTTI A，RUBINI G，et al. Contrast ? Enhanced Ultrasound Features of Malignant Focal Liver Masses in Dogs ［J］. Scientific Reports，2020，10（1）：6076?6087. ［23］MATSUYAMA A， BIENZLE D， RICHARDSON D， et al. Composite Lymphoma of Concurrent T Zone Lymphoma and Large Cell B Cell Lymphoma in a Dog［J］. BMC Veterinary Research，2019，15（1）：413?421. ［24］CHARLES J A，CULLEN J M，INGH T S G A M VAN DEN，et al. Morphological classification of neoplastic disorders of the canine and feline liver［M］. Elsevier. 2006：117?124. ［25］TOALDO M B， DIANA A， BETTINI G， et al. Imaging diagnosis ? cholangiocellular adenoma： contrast ? enhanced ultrasonographic findings of a benign tumor mimicking malignant neoplasia in a dog［J］. Veterinary Radiology & Ultrasound， 2012，54（1）：71?74. ［26］TAMURA M，NAKAMURA K，OSUGA T，et al. Findings of Contrast ? Enhanced Ultrasonography with Sonazoid for Cholangiocellular Adenoma in Three Dogs ［J］. Journal of Veterinary Medical Science，2019，81（8）：1104?1108.

[1]	袁媛1，龚晓佩1，王钰2，鲁浩坤1，胡莲美1，吴玄光1*. 一例犬特发性癫痫的诊断与治疗[J]. 广东畜牧兽医科技, 0, (): 37-40.
[2]	邱文粤，庞晓月，章心婷，黄健佳，周水莲，苏荣胜*. 犬特发性癫痫及其研究进展[J]. 广东畜牧兽医科技, 2022, 47(3): 92-97.