犬特发性癫痫及其研究进展

doi:10.19978/j.cnki.xmsy.2022.03.18

摘要/Abstract

摘要： 特发性癫痫是犬最常见的慢性神经系统疾病，近年来犬特发性癫痫的临床病例量日益增多，但部分宠物医生对于犬特发性癫痫的概念及其研究进展等情况尚不清晰，并且国内对于犬特发性癫痫的诊断和治疗方法的相关研究与国外还存在一定的差距。因此，本文主要介绍犬特发性癫痫的临床特征，并对国内外犬特发性癫痫诊断和治疗的研究进展做了总结，以期为临床宠物医生治疗犬特发性癫痫提供参考和促进犬特发性癫痫的相关研究。

关键词: 犬；特发性癫痫；癫痫发作特征；诊断；治疗

Abstract: Idiopathic epilepsy is the most common chronic disease of nervous system in dogs. In recent years， clinical cases of canine idiopathic epilepsy is increasing，but some pet doctors are still unclear about the concept and research progress of canine idiopathic epilepsy，and there is gap between domestic and foreign research on the diagnosis and treatment of canine idiopathic epilepsy. Therefore，this paper reviewed clinical characteristics of canine idiopathic epilepsy，and summarized the research progress of diagnosis and treatment of canine idiopathic epilepsy in China and abroad，in order to provide treatment reference for clinical pet doctors and promote the related research of canine idiopathic epilepsy.

Key words: Canines； Idiopathic Epilepsy； Seizure Characteristics； Diagnosis； Treatment

中图分类号:

S858.292

邱文粤，庞晓月，章心婷，黄健佳，周水莲，苏荣胜*. 犬特发性癫痫及其研究进展[J]. 广东畜牧兽医科技, 2022, 47(3): 92-97.

QIU Wenyue，PANG Xiaoyue，ZHANG Xinting，HUANG Jianjia，ZHOU Shuilian，SU Rongsheng*. Canine idiopathic epilepsy and its research progress[J]. Guangdong Journal of Animal and Veterinary Science, 2022, 47(3): 92-97.

参考文献

［1］ De RISIO L，BHATTI S，MUNANA K，et al. International veterinary epilepsy task force consensus proposal：diagnostic approach to epilepsy in dogs［J］. BMC Veterinary Research， 2015，11：148. ［2］ BERENDT M，FARQUHAR R G，MANDIGERS P J，et al. International veterinary epilepsy task force consensus report on epilepsy definition，classification and terminology in companion animals［J］. BMC Veterinary Research，2015，11：182. ［3］葛慎锋，刘长辉，沈文霞，等. 犬癫痫的病因、发病机制及病理变化［J］. 中国动物保健，2010，12（10）：50?52. ［4］侯加法. 犬猫癫痫的发病特征、鉴别诊断、抗痫药与其他治疗方法的研究进展［Z］. 广西，南宁：201915. ［5］林霖，丁轲. 犬癫痫发作的病因及治疗［J］. 现代农业科技， 2009（19）：322?323. ［6］ HULSMEYER V I，FISCHER A，MANDIGERS P J，et al. International Veterinary Epilepsy Task Force's current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs［J］. BMC Veterinary Research， 2015，11：175. ［7］ ERLEN A，POTSCHKA H，VOLK H A，et al. Seizures in dogs under primary veterinary care in the United Kingdom：Etiology， diagnostic testing，and clinical management［J］. Journal of Veterinary Internal Medicine，2020，34（6）：2525?2535. ［8］ BARNES H H. Update on anticonvulsant therapy in the emergent small animal patient［J］. The Veterinary clinics of North America. Small animal practice，2020，50（6）：1423?1431. ［9］ FISHER R S，ACEVEDO C，ARZIMANOGLOU A，et al. ILAE official report：a practical clinical definition of epilepsy［J］. Epilepsia，2014，55（4）：475?482. ［10］BRAY K Y，MARIANI C L，EARLY P J，et al. Continuous rate infusion of midazolam as emergent treatment for seizures in dogs ［J］. Journal of Veterinary Internal Medicine，2021，35（1）： 388?396. ［11］HALL R，LABRUYERE J，VOLK H，et al. Estimation of the prevalence of idiopathic epilepsy and structural epilepsy in a general population of 900 dogs undergoing MRI for epileptic seizures［J］. Veterinary Record，2020，187（10）：e89. ［12］THOMAS W B. Idiopathic epilepsy in dogs［J］. The Veterinary clinics of North America. Small animal practice，2000，30（1）： 183?206. ［13］RUSBRIDGE C，LONG S，JOVANOVIK J，et al. International Veterinary Epilepsy Task Force recommendations for a veterinary epilepsy ? specific MRI protocol［J］. BMC Veterinary Research，2015，11：194. ［14］PATTERSON E E，MICKELSON J R，DA Y，et al. Clinical characteristics and inheritance of idiopathic epilepsy in Vizslas ［J］. Journal of Veterinary Internal Medicine，2003，17（3）： 319?325. ［15］MELLEMA L M，KOBLIK P D，KORTZ G D，et al. Reversible magnetic resonance imaging abnormalities in dogs following seizures［J］. Vet Radiol Ultrasound，1999，40（6）：588?595. ［16］UNGER D M，WIEST R，KIEFER C，et al. Neuronal current imaging： An experimental method to investigate electrical currents in dogs with idiopathic epilepsy ［J］. Journal of Veterinary Internal Medicine，2021，35（6）：2828?2836. ［17］GONCALVES R，ANDERSON T J，INNOCENT G，et al. Effect of seizures on cerebrospinal fluid analysis in dogs with idiopathic epilepsy［J］. Veterinary Record，2010，166（16）：497?498. ［18］GILBERT S E，CARDY T J，BERTRAM S，et al. Diagnostic utility of cerebrospinal fluid analysis in dogs with suspected idiopathic epilepsy［J］. Australian Veterinary Journal，2021，99 （1?2）：1?5. ［19］CZERWIK A，PLONEK M，PODGORSKI P，et al. Comparison of electroencephalographic findings with hippocampal magnetic resonance imaging volumetry in dogs with idiopathic epilepsy ［J］. Journal of Veterinary Internal Medicine，2018，32（6）： 2037?2044. 临床诊疗犬特发性癫痫及其研究进展?邱文粤，等 · 96 · ［20］KOO Y，KIM H，YUN T，et al. Evaluation of serum high ? mobility group box 1 concentration in dogs with epilepsy：A case? control study［J］. Journal of Veterinary Internal Medicine， 2020，34（6）：2545?2554. ［21］STABILE F，VAN DIJK J，BARNETT C R，et al. Epileptic seizure frequency and semiology in dogs with idiopathic epilepsy after initiation of imepitoin or phenobarbital monotherapy［J］. Veterinary Journal，2019，249：53?57. ［22］TIPOLD A，KEEFE T J，LOSCHER W，et al. Clinical efficacy and safety of imepitoin in comparison with phenobarbital for the control of idiopathic epilepsy in dogs［J］. Journal of Veterinary Pharmacology and Therapeutics，2015，38（2）：160?168. ［23］STEE K， MARTLE V， BROECKX B， et al. Imepitoin withdrawal in dogs with idiopathic epilepsy well ?controlled with imepitoin and phenobarbital and/or potassium bromide does not increase seizure frequency［J］. Veterinary Journal，2017，230： 1?5. ［24］ROYAUX E，Van HAM L，BROECKX B J，et al. Phenobarbital or potassium bromide as an add ? on antiepileptic drug for the management of canine idiopathic epilepsy refractory to imepitoin ［J］. Veterinary Journal，2017，220：51?54. ［25］徐峰，戢翰升，戢太国. 胼胝体切开治疗顽固性癫痫（附102 例病例分析）［J］. 中国医药导刊，2013，15（2）：194?200. ［26］BAGLEY R S，BASZLER T V，HARRINGTON M L，et al. Clinical effects of longitudinal division of the corpus callosum in normal dogs［J］. Veterinary Surgery，1995，24（2）：122?127. ［27］张晨，王宣敬，刘斯汝，等. 犬癫痫病的中兽医治疗病例［J］. 中国兽医杂志，2020，56（05）：92?93. ［28］PANZER R B，CHRISMAN C L. An auricular acupuncture treatment for idiopathic canine epilepsy：a preliminary report ［J］. The American journal of Chinese medicine，1994，22（1）： 11?17. ［29］苏治国，陈文芳，解慧梅. 穴位埋线治疗犬原发性癫痫病的临床疗效试验［J］. 黑龙江畜牧兽医，2018（12）：152?153. ［30］梁丽丽，贾珊珊，李霞，等. 生酮饮食添加治疗儿童难治性癫痫的临床效果［J］. 临床医学研究与实践，2022，7（3）：21?24. ［31］BERK B A，LAW T H，PACKER R，et al. A multicenter randomized controlled trial of medium ?chain triglyceride dietary supplementation on epilepsy in dogs［J］. Journal of Veterinary Internal Medicine，2020，34（3）：1248?1259. ［32］BERK B A，PACKER R，LAW T H，et al. A double ? blinded randomised dietary supplement crossover trial design to investigate the short ?term influence of medium chain fatty acid （MCT）supplement on canine idiopathic epilepsy：study protocol ［J］. BMC Veterinary Research，2019，15（1）：181. ［33］FORSGARD J A，METSAHONKALA L，KIVIRANTA A M，et al. Seizure ? precipitating factors in dogs with idiopathic epilepsy ［J］. Journal of Veterinary Internal Medicine，2019，33（2）： 701?707.