关键词: 母猪； 猪圆环病毒3型； 近平滑假丝酵母菌； 混合感染

Abstract: In June 2022，sows in a large??scale pig farm in Longyan City，Fujian Province were reported ill in succession. The main clinical symptoms include slight swollen knee joints，reluctant to move or even difficulty instanding. In order to find out the causes of the disease，pathological examination was carried out on the diseased pigs. Blood samples were collected for nucleic acid detection of common pathogens and knee joint synovial fluid samples were collected for the isolation of microorganisms. The results showed that no obvious pathological changes were found in the main organs. The nucleic acid detection results of blood samples showed that porcine circovirus type 3（PCV3） was positive and no other major pathogens were detected. Microscopic examination of the microbial culture product of knee joint synovial fluid sample showed that there was yeast ?like fungus. PCR amplification and DNA sequencing of the cultured products showed that the yeast ?like fungus was Candida parapsilosis. Conclusion：This case is a mixed infection of PCV?3 and Candida parapsilosis. According to the literature，this is the first case in the world to report that Candida parapsilosis caused deep knee joint infection in pigs and Candida parapsilosis was successfully isolated from knee joint synovial fluid.

Key words: Sows； Porcine circovirus type 3； Candida parapsilosis； Co?infection