广东畜牧兽医科技 ›› 2023, Vol. 48 ›› Issue (3): 30-34.DOI: 10.19978/j.cnki.xmsy.2023.03.05

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长白母猪断奶至配种间隔全基因组关联分析

陈信佑1 ,林清1 ,张笑科1 ,李婷婷1 ,万鹏冲1 , 林长光2 ,黄珍3 ,谢水华4 ,张豪1 ,李加琪1*   

  1. (1.华南农业大学动物科学学院/广东省农业动物基因组学与分子育种重点实验室/国家生猪种 业工程技术研究中心,广东 广州 510642; 2.福建省农业科学院畜牧兽医研究所,福建 福州 350013; 3.广东艾佩克科技有限公司,广东 广州 510405; 4.广东省农业技术推广中心,广东 广州 510520)
  • 出版日期:2023-06-19 发布日期:2023-06-18
  • 通讯作者: 李加琪
  • 基金资助:
    国家生猪产业技术体系(CARS-35)

A Genome􀆼wide Association Study in Landrace Sows during Weaning􀆼to􀆼service Interval

CHEN Xinyou1 ,LIN Qing1 ,ZHANG Xiaoke1 ,LI Tingting1 ,WAN Pengchong1 ,LIN Changguang2 , HUAGN Zhen3 ,XIE Shuihua4 ,ZHANG Hao1 ,LI Jiaqi1*   

  1. (1. College of Animal Science,South China Agricultural University/Guangdong Key Laboratory of Agro?Animal Genomics and Molecular Breeding/National Engineering Research Center for Swine Breeding Industry, Guangzhou Guangdong 510642; 2. Institute of Animal Husbandry and Veterinary,Fujian Academy of Agricultural Science,Fuzhou Fujian 350013; 3.Guangdong iPig Technology Co.,Ltd,Guangzhou Guangdong 510405; 4.Agro??Tech Extension Center of Guangdong Province,Guangzhou Guangdong 510520)
  • Online:2023-06-19 Published:2023-06-18

摘要: 该研究旨通过全基因组关联分析定位影响长白母猪断奶至配种间隔的候选基因, 以期为我国种猪育种工作提供理论参考。本研究以国家某核心育种场1 063头长白母猪的断 奶至配种间隔记录和50 K基因数据为研究材料,利用GEMMA软件的混合线性模型进行全基 因组关联分析(GWAS),鉴定关联分析显著位点。结果表明,长白母猪第一胎次和第三胎次共 存在5个显著SNPs。对5个显著位点进行单倍型分析,获得4个单倍型块。筛选到的BTG1、 FUT1、FUT2、SCNN1G和CBLB基因可能是影响断奶至配种间隔性状的重要基因,该研究结果 可作为以后种猪育种实践提供参考。

关键词: 全基因组关联分析, 断配间隔, GEMMA, 长白猪

Abstract: The aim of this study was to detect candidate genes affecting the weaning ? to ? service interval of Landrace sows through the genome?wide association analysis(GWAS),in order to provide theoretical references for swine breeding in China. In this study, the weaning?to?service interval records and 50K gene data of 1 063 Landrace sows in a core breeding farm in China were used as research materials, and genome ? wide association analysis was performed by mixed linear models of GEMMA software to identify important loci. The results showed that there were 5significant SNPs in the first and third parity of Landrace sows. Haplotype analysis was performed on the 5 significant locus and 4 haplotype blocks were obtained. The screened genes of BTG1, FUT1, FUT2, SCNN1G, and CBLB may be the important genes affecting the weaning?to?servce interval traits. The results of this study can provide the reference for future practice of swine breeding.

Key words: Genome?wide association analysis, Weaning?to?serving interval, GEMMA, Landrace Sow

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