关键词: 替抗, 减抗, 天然产物, 畜禽健康

Abstract: The huge consumption of antibiotics by human and animal industry in the world has resulted in severe problems of bacterial resistance and drug residue，the rate and probability of the occurrence of“superbacteria” increased significantly，presenting threat to human and animal health. Although developed countries such as the Europe union and the United States of American，and our country，have successively issued a series of policies to decrease the consumption of antibiotics，its use in some developing countries such as Africa and Southeast Asia，still is insufficiently supervised and excessive used，and the long?term threat of bacterial resistance still exists. Therefore， the search of effective natural products to reduce the use of antibiotics is vital. Now，Chinese herbal medicine， probiotics，antimicrobial peptides，acidifiers，enzyme，and animal used marine drugs，all showed excellent antibacterial，anti?inflammatory，immunity enhancement，and growth?promoting functions. A green，antibiotics?free breeding technology in animal industry is of tendency in future. This paper reviewed the current situation of antibiotics used in China，as well as the antibiotics replacement products，focused on their function and acting mechanism， problems occurred in usage，and possible solutions for dealing with these problems.

Key words: Antibiotics, Replacement, Reduce, Natural product, Animal health