关键词: 鸡毒支原体, 呕吐毒素, 免疫抑制

Abstract: Mycoplasma gallitatis（MG）which often co?infect with Avian pathogenic Escherichia coli.（APEC）is an important pathogen for avian air saccultitis and put poultry industry in serious risks. In the meantime，mycotoxins as secondary metabolites produced by fungi or molds bring serious challenges to poultry health. In order to understand the correlation between mycotoxin and MG infection，7?day?old chickens were inoculated with MG S6 strain at 1×1010 CCU/mL for 3 days. Chickens were inoculated with avain pathogenic Escherichia coli（APEC）O78 strain at 1×107 CFU/mL 6 days later to induce the symptoms of diseases. During the experiment，8 mg/kg deoxynivalenol（DON）was fed through daily diet. The results showed that，at the condition of DON exposure，chickens did not show clinical symptoms of respiratory disease by MG and APEC infection，but the exposure of DON could significantly reduce the antibody level of MG and increase the detection rate of the MG in chicken blood. This study evaluated theimmunosuppressive ability of DON and confirmed that other pathogenic factors may be needed for the occurrence of multi etiological air saccultitis in chicks.

Key words: Mycoplasma gallitatis, Deoxynivalenol, Immunosuppression