关键词: 柴胡； 天麻； 中医药； 癫痫； 犬

Abstract: Epilepsy，or“Xian Disease”in Traditional Chinese Medicine，is one of the common neurological diseases. Traditional Chinese Medicine theory believes that the onset of epilepsy is often associated with the liver wind，so most of the time the liver treatment is elected which calms the liver wind and harmonize bodyand Qi. Bupleurum chinese DC. and Gastrodia elata Bl. are two kinds of traditional Chinese medicine commonly used in the treatment of epilepsy. The active ingredients of Bupleurum chinense DC have been suspected to conduct anti?epileptic effect by changing the intracellular ion concentration through multiple pathways，including regulating the secretion of neurotransmitters and significantly increasing the content of ATP by regulating the presynaptic calcium ion pathway. The active ingredients of Gastrodia elata Bl. can effectively change the pathological state of epilepsy by protecting neurons in the hippocampus， inhibiting inflammation in the hippocampus and regulating the secretion ofneurotransmitters. In this paper，the antiepileptic effect of these two Traditional Chinese Medicine was reviewed to provide references for clinical treatment and drug development for canine epilepsy.

Key words: Bupleurum chinense DC.； Gastrodia elata Bl.； Traditional Chinese medicine； Epilepsy； Dog